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A study of immunoglobulin G subclasses in patients with farmer's lung
Author(s) -
STOKES T. C.,
TURTON C. W. G.,
TURNERWARWICK M.
Publication year - 1981
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1981.tb01585.x
Subject(s) - farmer's lung , pathogenesis , immunology , antibody , lung , respiratory disease , blood bank , medicine , immunopathology , lung disease , gastroenterology , medical emergency
Summary A quantitative estimate of the IgG subclasses in patients with farmer's lung has revealed significantly higher IgG3 levels in patients with this condition compared to an age‐matched group of control farmers similarly exposed to Micropolyspora faeni ( P <0.01) and a group of normal blood bank donors ( P < 0.001). The IgG1 and total IgG levels were significantly higher in both groups of farmers compared to blood bank controls ( P <0.001). The possible significance of these observations is discussed in relation to susceptibility to the disease and its pathogenesis.