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Short and long latency skin sensitizing antibody in passive cutaneous anaphylaxis in the monkey
Author(s) -
HUTCHCROFT B. J.,
MOORE ELIZABETH G.,
ORANGE R. P.,
UNDERDOWN B. J.
Publication year - 1980
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1980.tb02145.x
Subject(s) - immunoglobulin e , immunology , antibody , blocking antibody , antigen , anaphylaxis , latency (audio) , allergy , medicine , chemistry , electrical engineering , engineering
In some allergic sera, 2-hr PCA responses can be due to IgE class antibody. In other sera where 2-hr PCA responses are not seen, removal of the IgG fracton allows expression of this 2-hr latency PCA response, suggesting an initial competition for binding sites between IgG and IgE, or that IgG can act as a blocking antibody, preventing antigen from reaching the cell-bound IgE.