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The role of calcium in the generation of intracellular SRS‐A in passively sensitized human lung challenged with antigen
Author(s) -
HUTCHCROFT B. J.,
ORANGE R. P.
Publication year - 1980
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1980.tb02138.x
Subject(s) - histamine , calcium , antigen , calcium in biology , intracellular , lung , chemistry , immunology , microbiology and biotechnology , medicine , pharmacology , endocrinology , biology , biochemistry
Summary Calcium deprivation inhibits the formation and subsequent release of SRS‐A as well as histamine from passively sensitized human lung fragments challenged with antigen. Antimycin A inhibits the release of histamine and SRS‐A in a dose dependant fashion, while causing a mild inhibition of SRS‐A formation throughout the dose range studied. These data suggest that the influx of calcium is the critical event for the generation of SRS‐A within the cell.