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A comparison of cell‐mediated immunity and suppressor T‐cell function in asthmatic and normal children
Author(s) -
HARPER T. B.,
GAUMER H. R.,
WARING W.,
BRAN R. B.,
SALVAGGIO J. E.
Publication year - 1980
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1980.tb02137.x
Subject(s) - suppressor , concanavalin a , immunology , cell , asthma , cell mediated immunity , t cell , medicine , disease , cell function , cellular immunity , immunity , immune system , biology , genetics , in vitro , cancer
Summary The role of general and suppressor T‐cell function was investigated in a group of twelve children with atopic asthma and ten non‐atopic control children. Studies of active E rosettes, lymphocyte stimulation, and delayed type skin responsiveness revealed no statistically significant group differences. Data obtained employing a concanavalin A‐induced, suppressor T‐cell assay revealed that the asthmatics generated significantly less suppressor cell activity than did the normal control group. There was no correlation between lack of suppressor cell function and serum IgE levels. The results of this study support the concept of suppressor T‐cell dysfunction in atopic disease.