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Long‐term study of flunisolide treatment in perennial rhinitis with special reference to nasal mucosal histology and morphology
Author(s) -
SAHAY J. N.,
IBRAHIM N. B. N.,
CHATTERJEE S. S.,
NASSAR W. Y.,
LODGE K. V.,
JONES C. W.
Publication year - 1980
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1980.tb02128.x
Subject(s) - medicine , histology , biopsy , mucous membrane of nose , infiltration (hvac) , cellular infiltration , dermatology , pathology , inflammation , physics , thermodynamics
Summary Ten patients with allergic perennial rhinitis completed a 3‐month course of treatment with flunisolide nasal spray†. Biopsy of the nasal mucosa was carried out before the initiation of treatment and at the end of the treatment period. The flunisolide was administered as a 0.025% solution twice daily at a total daily dose of 200μg. No histological abnormalities which could have been attributed to the effects of the drug were found in the post‐treatment biopsies. Comparison of the pre‐ and post‐treatment histological features showed either that there had been no apparent changes or that there had been a reduction in the oedema and/or cellular infiltration which had been present initially. All except one patient improved clinically and in this case the pre‐treatment nasal biopsy demonstrated features of atrophic rhinitis.