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PGF 2α challenge test in asthma and chronic bronchitis
Author(s) -
PARANTAINEN J.,
RITALA K.,
LAHDENSUO A.
Publication year - 1980
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1980.tb02095.x
Subject(s) - medicine , alpha (finance) , histamine , asthma , chronic bronchitis , bronchitis , clinical trial , gastroenterology , surgery , construct validity , patient satisfaction
Summary PGF 2SaL challenge tests were performed in twenty‐three patients with bronchial asthma and six patients with chronic bronchitis; two patients with allergic rhinitis and four healthy volunteers also participated in the trial. FEV 1 measurements were used in assessing the reactions. PGE 2α challenge proved safe and practical in clinical use. A wide scattering in PGF 2α reactivity was seen, but sensitivity to PGF 2α did not correlate to several clinical criteria. Comparison with an ordinary histamine challenge revealed that the sensitivity of the patients to PGF 2α and histamine was not uniform.