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Effect of FPL57787 in exercise‐induced asthma
Author(s) -
THOMSON N. C.,
GREEN A. G. H.,
KERR J. W.
Publication year - 1980
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1980.tb02078.x
Subject(s) - asthma , exercise induced asthma , medicine , physical therapy
Summary In ten patients with extrinsic asthma the effects of a new oral chromone FPL57787 and placebo were studied in a random double‐blind fashion to assess the effect of FPL57787 in preventing exercise‐induced asthma (EIA). Exercise testing consisted of steady state running on an inclined treadmill for up to 8 min. FPL57787 gave significant protection ( P < 0.01) compared to placebo from the maximum percentage fall in FEV 1 , FVC and MMEF after exercise. FPL57787 also produced a small but significant ( P < 0.01) percentage increase in FEV 1 , 2 hr after the drug compared to placebo, whereas no significant increase was seen in FVC or in MMEF.