Premium
T‐, B‐ and Fc‐γ‐receptor‐bearing lymphocytes in asthma
Author(s) -
CLOT J.,
BOUSQUET J.,
GUENDON R.,
MICHEL F. B.
Publication year - 1979
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1979.tb01550.x
Subject(s) - antiserum , rosette (schizont appearance) , receptor , rosette formation , immunology , antibody , immune system , asthma , fc receptor , lymphocyte , immunoglobulin e , immune complex , microbiology and biotechnology , chemistry , medicine , biology
Summary T‐, B‐ and Fc‐γ‐receptor‐bearing lymphocytes were detected using six different membrane markers in patients suffering from asthma having either normal or low serum IgA levels. E rosettes, aE rosettes and a human anti‐T lymphocyte antiserum (HTLA) were used for T cell determination. In patients with low serum IgA levels E rosettes were significantly decreased. B lymphocytes were identified by EAC rosette formation and visualization of surface membrane immunoglobulins (SmIg). No significant difference was seen. Fc‐γ‐receptor‐bearing lymphocytes were assessed by the EA rosette assay and were significantly decreased in asthmatics with normal IgA levels. This result might be explained by the presence of immune complexes.