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Oral acetylsalicylic acid (aspirin) challenge in asthmatic children
Author(s) -
SCHUHL J. F.,
PEREYRA J. G.
Publication year - 1979
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1979.tb01526.x
Subject(s) - aspirin , medicine , atopy , asthma , atopic dermatitis , eosinophilia , gastroenterology , anesthesia , immunology
Summary Thirty‐two asthmatic children, mean age 9.6 years (range: 6–14 years), were studied by oral challenge with acetylsalicylic acid (Aspirin), and their PEFR was recorded at 30 min intervals for 3 hr. They had been asthmatic for a mean of 7.1 years. Other allergic symptoms (urticaria, rhinitis or atopic dermatitis), were present in 81% of the patients, and a family history of atopy in 94%; the mean blood eosinophilia was 590 cells per mm 3 . In three children aspirin induced a fall in PEFR values less than 8% which was non‐significant. In the group as a whole there was an increase in the PEFR values of 13.9%, 150 min after aspirin challenge. These values where subjected to statistical analysis (Kolmogorov–Smirnov, Student's and Wilcoxon tests), which showed this increase to be significant at a level of P = 0.001. Possible mechanisms involving prostaglandin synthetase inhibition by aspirin are discussed as an explanation for this increase.