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Bronchial asthma and dermatitis due to spiramycin in a chick breeder
Author(s) -
PAGGIARO P. L.,
LOI A. M.,
TOMA G.
Publication year - 1979
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1979.tb00481.x
Subject(s) - spiramycin , medicine , allergy , antibiotics , asthma , radioallergosorbent test , budesonide , immunology , dermatology , allergen , microbiology and biotechnology , erythromycin , biology
Summary A case of bronchial asthma and dermatitis due to spiramycin is described in a non‐atopic woman who worked as a chick breeder and handling poultry feed containing antibiotic or chemoterapic drugs including spiramycin, chlortetracycline and sulfadimethoxine. Patch tests showed a vigorous delayed reaction to spiramycin. Inhalation challenge test with the chick feed containing spiramycin reproduced symptoms of late asthmatic response (FEV 1 fell by 14% and FEF 25–75 by 25% within the 4th and 6th hour) with leucocytosis. No significant modification of FEV 1 and FEF 25–75 was observed within 24 hours after challenge with chick feeds containing other antibiotic or chemotherapeutic agents but not spiramycin. On leaving her job, the patient had no further skin reactions or bronchial asthma episodes. This case suggests that allergic reactions to a chemical product may involve both type III and IV hypersensitivity.