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Treatment of chronic idiopathic urticaria with combined HI and H2 blockers
Author(s) -
PHANUPHAK P.,
SCHOCKET A.,
KOHLER P. F.
Publication year - 1978
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1978.tb01493.x
Subject(s) - medicine , chronic urticaria , hydroxyzine , cetirizine , omalizumab , cyproheptadine , angioedema , dermatology , cimetidine , anesthesia , immunoglobulin e , immunology , receptor , serotonin , antibody
Summary Combined H1 (cyproheptadine) and H2 antihistamines (cimetidine) were tried in eight patients with chronic urticaria who were previously unresponsive to conventional anti‐urticarial regimens, including type I antihistamines, hydroxyzine, ephedrine and corticosteroids. 50 % of the patients responded with 90 % or greater improvement within 10 days. The remaining 50% showed no benefit. Side effects of the medications were minimal. These results indicate that a 10 day trial of both H1 and H2 antihistamines may be useful in patients with chronic urticaria resistant to all other standard treatment modalities.