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Familial human short‐term sensitizing (IgG S‐TS) antibody
Author(s) -
BERRY J. B.,
BRIGHTON W. D.
Publication year - 1977
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1977.tb01470.x
Subject(s) - immunoglobulin e , immunology , pollen , antibody , titer , medicine , biology , botany
Summary Skin tests on a middle‐aged English housewife (the initial case) with a history of seasonal grass pollen rhinitis and asthma showed strong immediate and late reactions to grass pollens. Early in the grass pollen season, 1976, RAST showed normal levels of IgE antibodies in the serum. Passive transfer in Rhesus monkey skin was also negative for heat‐labile IgE but gave a very vigorous reaction for short‐term sensitizing heat‐stable IgG antibody (IgG S‐TS Ab). Skin tests and studies on sera from other members of the family showed that another five also formed IgG S‐TS Ab, and indicated that the ability to form this antibody was familial. One member of the family had only an immediate reaction on skin testing, and much IgE to grass pollen. Towards the end of the grass pollen season the IgE titre in the initial case had been tripled and the IgG S‐TS Ab had disappeared. By September the specific IgE titre had risen even further.