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A trial of ICI 74,917 in seasonal allergic rhinitis
Author(s) -
BLAIR H.
Publication year - 1977
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1977.tb01469.x
Subject(s) - placebo , medicine , nostril , randomized controlled trial , allergy , placebo group , surgery , nose , immunology , pathology , alternative medicine
Summary Twenty‐four patients with seasonal allergic rhinitis were treated in a randomized double‐blind trial of 6 weeks’ duration, using either ICI 74,917 (0.5 mg in each nostril four times a day) or an identical placebo aerosol. Four patients receiving placebo were withdrawn from the trial because of the deterioration in their rhinitis. The twelve patients using ICI 74,917 were protected as assessed by a combined total symptom score, which was statistically significant ( P <0.05), from weeks 1 to 4 when the pollen counts were highest.