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Antigens in pigeon breeder's disease
Author(s) -
TEBO THOMAS H.,
MOORE VER L.,
FINK JORDAN N.
Publication year - 1977
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1977.tb01430.x
Subject(s) - antigen , breeder (animal) , immunology , disease , biology , medicine , political science , pathology , blanket , law
Summary Sera from patients with pigeon breeder's disease were analysed for precipitating antibodies by immunodiffusion and immunoelectrophoresis using whole pigeon dropping extract (PDE) and a purified fraction of PDE (PDE 1 ) as antigens. For comparison, sera from asymptomatic pigeon breeders and normal individuals were also tested for precipitating antibodies. Whereas whole PDE formed precipitin lines with normal serum as well as with serum from symptomatic and asymptomatic pigeon breeders. PDE, formed precipitin lines only with serum from individuals exposed to pigeons. This suggests that whole PDE forms non‐specific (non‐antigen‐antibody reactions) as well as specific precipitin lines, while PDE 1 appears to form only specific lines. These data indicate that whole PDE has limited usefulness in studies of pigeon breeder's disease. It is also possible that PDE 1 will be useful in studies of this disease.