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Asthma due to inhaled chemical agents—epoxy resin systems containing phthalic acid anhydride, trimellitic acid anhydride and triethylene tetramine
Author(s) -
FAWCETT I. W.,
NEWMAN TAYLOR A. J.,
PEPYS J.
Publication year - 1977
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1977.tb01418.x
Subject(s) - phthalic anhydride , trimellitic anhydride , toluene diisocyanate , toluene , isocyanate , epoxy , chemistry , phthalic acid , organic chemistry , tetramine , polymer chemistry , polyurethane , catalysis
Summary Six workers with a diagnosis of occupational asthma and one with chronic bronchitis were examined for sensitivity to epoxy resin systems and certain of their components. In six cases the chemical agent responsible for their symptoms was identified by careful inhalation challenge testing, simulating their exposure at work and thus providing a precise aetiological diagnosis. In one worker asthma followed exposure to triethylene tetramine fume; four were sensitive to acid anhydrides, three to phthalic acid anhydride as a fume or powder and one to trimellitic anhydride. One worker thought to be sensitive to toluene di‐isocyanate gave negative reactions to this and positive reactions to a phthalic acid anhydride epoxy resin and another thought to have asthma from acid anhydride fumes was found to be sensitive only to toluene di‐isocyanate. Immediate, non‐immediate or combined asthmatic reactions were elicited.