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The inhibition of allergen induced bronchospasm in man by oral BRL 10833
Author(s) -
PAUWELS R.,
LAMONT H.,
STRAETEN M.
Publication year - 1976
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1976.tb01931.x
Subject(s) - bronchoconstriction , bronchospasm , inhalation , allergen , medicine , ingestion , asthma , bronchial spasm , allergy , immunology , pharmacology , anesthesia
Summary BRL 10833, a nitroindanedione, with DSCG like activity in rat immediate type hypersensitivity, shows good absorption after oral intake in man. The ingestion of 2 and 10 mg BRL 10833/kg body weight provides protection against the immediate type allergen induced bronchoconstriction in patients with bronchial asthma. These results confirm the activity of the drug already shown by inhalation.