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The relationship between bronchial histamine reactivity and atopic status
Author(s) -
BRYANT D. H.,
BURNS M. W.
Publication year - 1976
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1976.tb01919.x
Subject(s) - atopy , histamine , asthma , immunology , immunoglobulin e , reactivity (psychology) , medicine , allergy , pathology , antibody , alternative medicine
Summary It has been proposed that increased production of IgE, a feature of atopy, is a cause of the non‐specific bronchial hyper‐reactivity that is characteristic of asthma. This hypothesis was examined by selecting groups of subjects with asthma or rhinitis and a group of healthy control subjects and studying the relationship between their bronchial histamine reactivity and their atopic status. In none of the groups tested was there a significant association between the degree of bronchial histamine reactivity and either the serum level of total IgE or the number of extracts of aero‐allergens giving positive prick test reactions.