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Intranasal steroid aerosol in perennial rhinitis: comparison with an antihistamine compound
Author(s) -
HARDING S. M.,
HEATH S.
Publication year - 1976
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1976.tb01918.x
Subject(s) - antihistamine , medicine , topical steroid , nose , nasal administration , fluticasone propionate , aerosol , betamethasone , steroid , asthma , anesthesia , dermatology , pharmacology , chemistry , surgery , organic chemistry , hormone
Summary Intranasal betamethasone valerate aerosol, given for 28 days, was compared with an oral antihistamine compound in a double‐blind, double‐dummy, cross‐over trial involving thirty patients with perennial rhinitis. The steroid aerosol was more effective in reducing symptoms and was preferred by the patients ( P < 0·01). Nasal blockage index, calculated from oral and nasal peak expiratory flow measurements, did not provide useful or additional information. There were no side effects from the steroid and Candida albicans was not cultured from nasal swabs. It is concluded that beta‐methasone valerate aerosol is a suitable short‐term alternative for patients whose perennial rhinitis fails to respond to conventional therapy.