Premium
Asthma due to non‐occupational exposure to toluene (tolylene) di‐isocyanate
Author(s) -
CARROLL K. B.,
SECOMBE C. J. P.,
PEPYS J.
Publication year - 1976
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1976.tb01886.x
Subject(s) - toluene diisocyanate , isocyanate , occupational asthma , toluene , polyurethane , occupational exposure , asthma , etiology , medicine , chemistry , organic chemistry , environmental health , immunology
Summary The production of asthma by toluene di‐isocyanate, aspirated into the ventilating system and emanating from the exhausts of a neighbouring factory, was established in three otherwise non‐exposed clerical workers. Occupational‐type exposure tests with a polyurethane varnish/toluene di‐isocyanate mixture elicited vigorous and prolonged non‐immediate asthmatic reactions, thus enabling identification of the otherwise, obscure etiological cause of their asthma.