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Antibodies mediating type I skin test reactions to polysaccharide and protein antigens of Candida albicans
Author(s) -
LONGBOTTOM JOAN L.,
BRIGHTON W. D.,
EDGE GERALDINE,
PEPYS J.
Publication year - 1976
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1976.tb01410.x
Subject(s) - mannan , candida albicans , polysaccharide , antibody , concanavalin a , antigen , glycoprotein , chemistry , microbiology and biotechnology , cell wall , corpus albicans , biochemistry , biology , immunology , in vitro
Summary Immediate, type I, prick test reactions in man to purified fractions of Candida albicans group A were mediated by different classes of antibody. The allergens were the cell‐wall polysaccharide, mannan, and a ‘purified’ cytoplasmic protein fraction, free of mannan, prepared by passage through Sepharose‐concanavalin‐A. Passive transfer tests in the monkey gave immediate reactions, (1) to the purified, cytoplasmic, protein mediated by heat‐labile long‐term sensitizing antibody, and (2) to the polysaccharide, mannan, mediated by heat‐stable short‐term sensitizing antibody.