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Morphological changes of basophils in immunological reactions—effect of sodium cromoglycate
Author(s) -
KIMURA IKURO,
TANIZAKI YOSHIRO,
SATO SHUICHI,
TAKAHASHI KIYOSHI,
SAITO KATSUYOSHI,
UEDA NOBUO
Publication year - 1975
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1975.tb01851.x
Subject(s) - sodium cromoglycate , immunology , cromolyn sodium , chemistry , disodium cromoglycate , medicine , asthma
Summary The morphological changes in blood basophils, from patients with bronchial asthma, were studied in vitro during immunological reactions, with particular reference to interaction with anti‐IgE. Anti‐human IgE results in an absolute reduction in basophil numbers in buffy coat preparations as well as basophil cytoplasmic degranulation. An increase in the numbers of pear‐shaped (A‐form) basophils is also observed. Sodium cromoglycate impairs all these anti‐IgE induced basophil changes, providing further insight into the mechanism of action of this compound in bronchial asthma.