Premium
Experimental extrinsic allergic alveolitis induced in the guinea‐pig with Streptomyces olivaceus
Author(s) -
BLACKBURN C. R. B.,
GREEN W. F.
Publication year - 1974
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1974.tb01366.x
Subject(s) - antigen , guinea pig , microbiology and biotechnology , biology , immunology , inhalation , anatomy , endocrinology
Summary Streptomyces olivaceus was isolated from the roof‐thatch of New Guinea huts, and a soluble extract was prepared from it. Using sera from New Guinea natives as a source of precipitating antibody, the S. olivaceus antigen showed a reaction of partial identity with antigens in crude roof‐thatch extracts. The inhalation of aerosols of S. olivaceus antigen by guinea‐pigs, previously given parenteral doses of the same antigenic solution, induced extrinsic allergic alveolitis.