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A fine structure study of some cellular components in allergic reactions 1. Degranulation of human mast cells in allergic asthma and perennial rhinitis
Author(s) -
TROTTER C. M.,
ORR T. S. C.
Publication year - 1973
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1973.tb01349.x
Subject(s) - degranulation , granule (geology) , mast cell , membrane , asthma , ultrastructure , immunology , allergy , pathology , chemistry , medicine , materials science , composite material , biochemistry , receptor
Summary Tissues from patients with allergic asthma or perennial rhinitis have been examined and normal mast cell ultrastructure described. Degranulating mast cells are shown in nasal and bronchiolar tissue, with attention focused on granules, microfilaments and labyrinth and pore formations. Five stages of degranulation are described: (1) disappearance of granule lamellae; (2) swelling of area within perigranular membrane; (3) fusion of perigranular membranes or fusion of perigranular and plasma membranes; (4) perforation of fused perigranular and plasma membranes; (5) extrusion of granules.