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Metabolic changes in exercise‐induced asthma
Author(s) -
BARBORIAK J. J.,
SOSMAN A. J.,
FINK J. N.,
MAKSUD M. G.,
McCONNELL L. H.,
HAMILTON L.
Publication year - 1973
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1973.tb01312.x
Subject(s) - bronchoconstriction , medicine , asthma , bicycle ergometer , epinephrine , exercise induced asthma , lactic acid , physical exercise , respiratory exchange ratio , respiratory system , endocrinology , physical therapy , heart rate , blood pressure , biology , bacteria , genetics
Summary Five patients with a history of post‐exercise bronchoconstriction and eleven control subjects were exposed to gradually increasing work loads on a bicyle ergometer. The asthmatic patients showed higher blood lactic acid levels at all work loads than the control subjects. In contrast to findings in the controls, the plasma free fatty acid in the asthmatics failed to ‘rebound’ following the cessation of exercise; and in two out of three patients plasma FFA did not rise after epinephrine injection. In addition, the asthmatic patients consumed less oxygen during the exercise than the controls. The results of this study suggest that patients with post‐exercise asthma may have to rely more on carbohydrates as the main source of energy because of the reduced availability of FFA. Since the consumption of oxygen is also reduced, this may lead to a higher lactate production.