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Asthma due to inhaled chemical agents—complex salts of platinum
Author(s) -
PEPYS J.,
PICKERING C. A. C.,
HUGHES E. G.
Publication year - 1972
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1972.tb01303.x
Subject(s) - occupational asthma , inhalation , medicine , platinum , asthma , allergy , immunology , chemistry , anesthesia , organic chemistry , catalysis
Summary Sixteen workers, from a platinum refinery, with respiratory disease were tested with solutions of complex salts of platinum and ten gave immediate prick test reactions to concentrations of 10 −4 −10 −6 and immediate nasal reactions in seven out of eleven tested to concentrations of 10 3 −10 −8 . Occupational‐type exposure inhalation tests to the dust from mixtures of 40 mg of the platinum salt with 1 kg of lactose gave immediate asthmatic reactions in eight and in one of these a late reaction, all also giving immediate prick test reactions. The asthmatic reactions were inhibited by disodium cromoglycate. In two with negative prick tests, late asthmatic reactions were elicited. The occupational‐type exposure test provides a safe, acceptable procedure for etiological diagnosis.