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Detection of penicillin allergy of the immediate type by radioimmunoassay of reagins (IgE) to penicilloyl conjugates
Author(s) -
WIDE LEIF,
JUHLIN LENNART
Publication year - 1971
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1971.tb03016.x
Subject(s) - penicillin , provocation test , radioallergosorbent test , immunology , radioimmunoassay , immunoglobulin e , medicine , allergy , penicillin allergy , anaphylaxis , antibody , antibiotics , microbiology and biotechnology , biology , pathology , alternative medicine
Summary Reaginic antibodies (IgE) to penicilloyl were detected by an in vitro method, a radioimmunological technique (RAST), in the sera of nine patients out of eleven with a recent history of penicillin hypersensitivity of the immediate type. Provocation tests in two patients with negative RAST were negative as well as in twelve patients having had a possible penicillin hypersensitivity reaction 7 months to 14 years ago. Results from skin tests and RAST agreed. Skin tests and RAST reactions were negative for thirty‐two patients with a history of penicillin reactions of the delayed type. The results of this study indicate that the RAST is a valuable alternative to the more dangerous intracutaneous test with penicilloyl‐polylysine for‐detection of penicillin hypersensitivity of the immediate type.