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Allergic broncho‐pulmonary aspergillosis Clinical immunology: (2) Skin, nasal and bronchial tests
Author(s) -
McCARTHY D. S.,
PEPYS J.
Publication year - 1971
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1971.tb00793.x
Subject(s) - allergic bronchopulmonary aspergillosis , medicine , aspergillus fumigatus , allergy , immunology , inhalation , aspergillosis , precipitin , extrinsic allergic alveolitis , hypersensitivity reaction , pulmonary aspergillosis , asthma , allergen , lung , immunoglobulin e , anesthesia , antibody
Summary Skin, nasal and bronchial tests with extracts of Aspergillus fumigatus and in particular with its protein fraction elicit dual. Type I plus Type III, allergic reactions in all three organs in patients suffering from allergic broncho‐pulmonary aspergillosis. The immediate asthmatic reaction is readily reversible and less severe than the late asthmatic reaction which lasts for many hours and is only temporarily reversed by the inhalation of isoprenaline. The late reaction develops slowly in contrast to the acute onset of the immediate reaction and may be accompanied by fever and leucocytosis. The dual nasal reaction elicited in patients with allergic broncho‐pulmonary aspergillosis contrasts with the production of only an immediate nasal reaction in subjects with Type I allergy and no precipitins.