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The Millennium Cohort Study Child Health Group Factors associated with uptake of measles, mumps, and rubella vaccine (MMR) and use of single antigen vaccines in a contemporary UK cohort: prospective cohort study
Author(s) -
Reading Richard
Publication year - 2008
Publication title -
child: care, health and development
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.832
H-Index - 82
eISSN - 1365-2214
pISSN - 0305-1862
DOI - 10.1111/j.1365-2214.2008.00864_1.x
Subject(s) - medicine , measles , cohort , mmr vaccine , rubella , rubella vaccine , pediatrics , immunization , cohort study , measles mumps rubella vaccine , vaccination , confidence interval , immunology , demography , antigen , sociology
The Millennium Cohort Study Child Health Group Factors associated with uptake of measles, mumps, and rubella vaccine (MMR) and use of single antigen vaccines in a contemporary UK cohort: prospective cohort study.
Pearce A. , Law C. , Elliman D. , Cole T. J. & Bedford H.(2008)British Medical Journal,336,754–757.
DOI: 10.1136/bmj.39489.590671.25.Objectives To estimate uptake of the combined measles, mumps, and rubella vaccine (MMR) and single antigen vaccines and explore factors associated with uptake and reasons for not using MMR. Design Nationally representative cohort study. Setting Children born in the UK, 2000–2002. Participants A total of 14 578 children for whom data on immunization were available. Main outcome measures Immunization status at 3 years defined as ‘immunized with MMR’, ‘immunized with at least one single antigen vaccine’, and ‘unimmunized’. Results In total, 88.6% (13 013) were immunized with MMR and 5.2% (634) had received at least one single antigen vaccine. Children were more likely to be unimmunized if they lived in a household with other children (risk ratio 1.74, 95% confidence interval 1.35 to 2.25, for those living with three or more) or a lone parent (1.31, 1.07 to 1.60) or if their mother was under 20 (1.41, 1.08 to 1.85) or over 34 at cohort child's birth (reaching 2.34, 1.20 to 3.23, for ≥40), more highly educated (1.41, 1.05 to 1.89, for a degree), not employed (1.43, 1.12 to 1.82), or self‐employed (1.71, 1.18 to 2.47). Use of single vaccines increased with household income (reaching 2.98, 2.05 to 4.32, for incomes of ≥£52 000 (€69 750, $102 190)), maternal age (reaching 3.04, 2.05 to 4.50, for ≥40) and education (reaching 3.15, 1.78 to 5.58, for a degree). Children were less likely to have received single vaccines if they lived with other children (reaching 0.14, 0.07 to 0.29, for three or more), had mothers who were Indian (0.50, 0.25 to 0.99), Pakistani or Bangladeshi (0.13, 0.04 to 0.39), or black (0.31, 0.14 to 0.64), or aged under 25 years (reaching 0.14, 0.05 to 0.36, for 14–19). Nearly three‐quarters (74.4%, 1110) of parents who did not immunize with MMR made a ‘conscious decision’ not to immunize. Conclusions Although MMR uptake in this cohort is high, a substantial proportion of children remain susceptible to avoidable infection, largely because parents consciously decide not to immunize. Social differentials in uptake could be used to inform targeted interventions to promote uptake.