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Age at first measles‐mumps‐rubella vaccination in children with autism and school‐matched control subjects: a population‐based study in metropolitan Atlanta
Author(s) -
Reading Richard
Publication year - 2004
Publication title -
child: care, health and development
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.832
H-Index - 82
eISSN - 1365-2214
pISSN - 0305-1862
DOI - 10.1111/j.1365-2214.2004.435_6_6.x
Subject(s) - birth certificate , medicine , vaccination , measles , confidence interval , population , pediatrics , odds ratio , rubella , autism , demography , mmr vaccine , logistic regression , diphtheria , environmental health , immunology , psychiatry , sociology , pathology
Age at first measles‐mumps‐rubella vaccination in children with autism and school‐matched control subjects: a population‐based study in metropolitan Atlanta.
DeStefano , F. , Karapurkar Bhasin , T. , Thompson , W.T. , Yeargin‐Allsopp , M. & Boyle , C.(2004)Pediatrics113,259–266.Objective To compare ages at first measles‐mumps‐rubella (MMR) vaccination between children with autism and children who did not have autism in the total population and in selected subgroups, including children with regression in development. Methods A case–control study was conducted in metropolitan Atlanta. Case children ( n = 624) were identified from multiple sources and matched to control children ( n = 1824) on age, gender and school. Vaccination data were abstracted from immunization forms required for school entry. Records of children who were born in Georgia were linked to Georgia birth certificates for information on maternal and birth factors. Conditional logistic regression was used to estimate odds ratios (ORs). Results The overall distribution of ages at MMR vaccination among children with autism was similar to that of matched control children; most case (70.5%) and control children (67.5%) were vaccinated between 12 and 17 months of age. Similar proportions of case and control children had been vaccinated before 18 or before 24 months. No significant associations for either of these age cut‐offs were found for specific case subgroups, including those with evidence of developmental regression. More case (93.4%) than control children (90.6%) were vaccinated before 36 months [OR 1.49, 95% confidence interval (CI) 1.04–2.14 in the total sample; OR 1.23, 95% CI 0.64–2.36 in the birth certificate sample). This association was strongest in the 3–5 years age group. Conclusions Similar proportions of case and control children were vaccinated by the recommended age or shortly after (i.e. before 18 months) and before the age by which atypical development is usually recognized in children with autism (i.e. 24 months). Vaccination before 36 months was more common among case children than control children, especially among children 3–5 years of age, likely to reflect immunization requirements for enrolment in early intervention programmes.