Open AccessNotch signalling pathway in tooth development and adult dental cells
Author(s) -
Cai X.,
Gong P.,
Huang Y.,
Lin Y.
Publication year - 2011
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.2011.00780.x
Subject(s) - notch signaling pathway , microbiology and biotechnology , odontoblast , wnt signaling pathway , biology , stem cell , signal transduction , hes3 signaling axis , regeneration (biology) , anatomy , pulp (tooth) , pathology , medicine
Notch signalling is a highly conserved intercellular signal transfer mechanism that includes canonical and non‐canonical pathways. It regulates differentiation and proliferation of stem/progenitor cells by means of para‐inducing effects. Expression and activation of Notch signalling factors (receptors and ligands) are critical not only for development of the dental germ but also for regeneration of injured tissue associated with mature teeth. Notch signalling plays key roles in differentiation of odontoblasts and osteoblasts, calcification of tooth hard tissue, formation of cusp patterns and generation of tooth roots. After tooth eruption, Notch signalling can also be triggered in dental stem cells of the pulp, where it induces them to differentiate into odontoblasts, thus generating fresh dentine tissue. Other signalling pathways, such as TGFβ, NF‐κB, Wnt, Fgf and Shh also interact with Notch signalling during tooth development.