Open AccessMonitoring the fidelity of mitotic chromosome segregation by the spindle assembly checkpoint
Author(s) -
Silva P.,
Barbosa J.,
Nascimento A. V.,
Faria J.,
Reis R.,
Bousbaa H.
Publication year - 2011
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.2011.00767.x
Subject(s) - spindle checkpoint , anaphase , microbiology and biotechnology , chromosome segregation , mitosis , aneuploidy , spindle apparatus , metaphase , chromosome instability , chromosome , biology , kinetochore , genetics , cell division , cell , gene
Accurate chromosome segregation relies on activity of the spindle assembly checkpoint, a surveillance mechanism that prevents premature anaphase onset until all chromosomes are properly attached to the mitotic spindle apparatus and aligned at the metaphase plate. Defects in this mechanism contribute to chromosome instability and aneuploidy, a hallmark of malignant cells. Here, we review the molecular mechanisms of activation and silencing of the spindle assembly checkpoint and its relationship to tumourigenesis.