Open AccessCdc2: a monopotent or pluripotent CDK?
Author(s) -
Hu X.,
Moscinski L. C.
Publication year - 2011
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.2011.00753.x
Subject(s) - cyclin dependent kinase 1 , cyclin dependent kinase , interphase , microbiology and biotechnology , biology , cyclin b1 , cell cycle , cell , biochemistry
Cell cycle progression is controlled by both extracellular and intracellular signalling molecules. It has been generally believed that cdc2/CDK1 only control G 2 ‐M transition in mammalian and many other higher eukaryotic cells. Accumulating evidence shows that cdc2 not only promotes G 2 ‐M transition but is also capable of regulating G 1 progress and G 1 ‐S transition via association with multiple interphase cyclins; cdc2 activity can be inhibited by p21 and p27, two traditional G 1 CDK inhibitors. In addition, cdc2‐cyclin B controls pronuclear union in interphase fertilized eggs. These data suggest that cdc2 may be a pluripotent CDK. Although mechanisms responsible for the multiple functions of cdc2 remain to be further investigated, interactions of cdc2 with pRb and with several important transcription factors may provide a clue to the pluripotent role of cdc2.