Open AccessNeutropenia dynamics in a case of T‐LGL lymphoproliferation illustrate rapid turnover of granulocyte progenitors
Author(s) -
Wolfrom C. M.,
Lévy V.,
Deschatrette J.
Publication year - 2010
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.2010.00678.x
Subject(s) - neutropenia , granulocyte , progenitor cell , immunology , bone marrow , lymphocyte , biology , dynamics (music) , progenitor , microbiology and biotechnology , chemotherapy , stem cell , physics , genetics , acoustics
Objectives: To elucidate the natural history of T‐cell large granular lymphocyte (T‐LGL) lymphoproliferation, we followed changes in associated fluctuating neutropenia for 3 years in an untreated patient presenting with the disease. Materials and methods: We report a nonlinear mathematical analysis of irregular neutrophil fluctuation, using iterative data maps, to detect long‐term regulation of the neutrophil population. Results: This geometric analysis indicated that variations of this sequence of neutrophil counts followed bounded deterministic dynamics around a fixed low level equilibrium, a situation similar to that previously observed for cultured mouse early bone marrow progenitor cells. Conclusion: These findings illustrate how the deleterious effect of T‐LGL on neutrophils is balanced, over periods of years, by pulses of compensatory neutrophil production, potentially accounting for the commonly observed prolonged indolent course of the disease.