Open AccessA novel type II membrane receptor up‐regulated by IFN‐α in fibroblasts functions in cell proliferation through the JAK‐STAT signalling pathway
Author(s) -
Liu L.D.,
Dong C.H.,
Shi H.J.,
Zhao H.L.,
Wang L.C.,
Ma S.H.,
Li Q.H.
Publication year - 2006
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.2006.00373.x
Subject(s) - microbiology and biotechnology , fibroblast , signal transduction , cell growth , immunofluorescence , receptor , biology , stat , jak stat signaling pathway , cell surface receptor , cell type , cell , cell culture , antibody , immunology , biochemistry , genetics , stat3 , tyrosine kinase
. A type II membrane protein similar to CD69 (TIIMPSC) has been isolated in human embryo fibroblasts treated with IFN‐α. Structural analysis and immunofluorescence detection has suggested that this protein is located on the surface of fibroblasts, generally considered, a receptor. Cell proliferation assay has revealed that activation of TIIMPSC elevates the level of fibroblast proliferation. Further, examination of signal transduction has indicated that expression of this protein is up‐regulated by IFN‐α stimulation, and that it is involved in the regulation of fibroblast growth through the JAK‐STAT signalling pathway.