Open AccessCircadian variation of the cell proliferation in the jejunal epithelium of rats at weaning phase
Author(s) -
Gomes J. R.,
Pereira A. A. M.,
Barth L.,
Silva J. S.,
Leite M. L.,
Wille A. C. M.,
Soares M. A. M.
Publication year - 2005
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.2005.00339.x
Subject(s) - circadian rhythm , crypt , biology , weaning , epithelium , metaphase , cell growth , period (music) , andrology , medicine , endocrinology , chromosome , genetics , gene , physics , acoustics
. Circadian variation in cell proliferation of the jejunal epithelium of 18‐day‐old rats was studied using the 2‐h arrested metaphase score and crypt isolation method. A continuous decrease in the arrested metaphases occurred from 07.00 h to13.00 h. From 17.00 h arrested metaphase values increased and were maintained at the higher level during the dark period as showed by Cosinor analyses ( P < 0.05). These results indicate that in the young rat there is already a circadian variation in jejunal epithelial cell proliferation as early as 18 days. We can even suggest that the presence of a circadian rhythm at weaning contributes to the steady state of cell proliferation in the intestinal epithelium observed in adult life.