Open AccessThe GC factor regulates the expression of the insulin‐like growth factor‐I receptor
Author(s) -
Morrione A.,
DeAngelis T.,
Baserga R.
Publication year - 1995
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1995.tb00052.x
Subject(s) - regulator , transfection , growth factor , insulin like growth factor , receptor , biology , microbiology and biotechnology , cell culture , cell growth , insulin , in vitro , insulin like growth factor receptor , chemistry , endocrinology , gene , genetics
We have transfected a plasmid expressing the transcriptional regulator GC Factor (GCF) into cell lines and have found that the GCF: 1 causes a decrease in the levels of insulin‐like growth factor I receptor (IGF‐IR) mRNA; 2 causes a decrease in the number of IGF‐IRs; and 3 represses the activity of the IGF‐IR promoter. In addition, we show that the regulation of IGF‐IR expression by GCF plays a physiological role in the control of cellular proliferation in vitro .