Open AccessS‐phase cell fraction in the prognosis of Dukes' stage D colorectal carcinoma
Author(s) -
Faranda A.,
Costa A.,
Silvestrini R.,
Quagliuolo V.,
Gennari L.
Publication year - 1994
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1994.tb01493.x
Subject(s) - stage (stratigraphy) , carcinoma , ploidy , cell , colorectal cancer , biology , medicine , pathological , pathology , oncology , cancer , genetics , paleontology , gene
. The S‐phase cell fraction was prospectively defined as the [ 3 H]‐thymidine labeling index ([ 3 H]dT LI) and flow cytometric S‐phase (FCM‐S) on 52 Dukes' D colorectal cancers. FCM‐S estimates obtained by using different modeling systems were superimposible but they were weakly related to [ 3 H]dT LI detected on the same tumour. Moreover, FCM‐S values were higher in aneuploid than in diploid tumours, whereas [ 3 H]dT LI values were independent of DNA‐ploidy status. [ 3 H]dT LI and FCM‐S were also related differently to some clinical and pathological features such as tumour site and histology. [ 3 H]dT LI and FCM‐S were indicative of prognosis in terms of 2–year freedom from progression and overall survival. However, product‐limit survival analysis showed an unexpectedly better freedom from progression and overall survival for patients with high S‐phase tumours than for those with low S‐phase tumours as defined by both cell kinetic variables.