Open AccessOrigin and evolution of binucleate cells in cultures of HEp‐2 cells
Author(s) -
Serrano A.,
Rodilla V.,
Pellicer J. A.,
Pertusa J.
Publication year - 1994
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1994.tb01410.x
Subject(s) - mitosis , biology , cell division , microbiology and biotechnology , cytological techniques , binucleated cells , cell , chemistry , genetics , pathology , micronucleus , micronucleus test , organic chemistry , toxicity , medicine
. The origin and evolution of binucleate cells in cultures of HEp‐2 cells have been studied by means of interval photography and time‐lapse video‐recording. Binuc leate cells most frequently formed by the fusion of two sister cells born in a previous mitosis. The study of binucleate cells has shown that they are a cellular type able to successfully undergo mitosis. However, the mitosis may be bipolar, tripolar or multi‐polar. The daughter cells arising from these divisions do not follow a clear pattern in the number of nuclei they have, instead showing a wide range of possibilities.