Open AccessA model for regulation of the cell cycle incorporating cyclin A, cyclin B and their complexes
Author(s) -
Obeyesekere M. N.,
Tucker S. L.,
Zimmerman S. O.
Publication year - 1994
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1994.tb01409.x
Subject(s) - cdc25 , cyclin , cell cycle , cyclin a , microbiology and biotechnology , cyclin b , cyclin dependent kinase 1 , biology , cyclin e , cell , biochemistry
. t. A mathematical model for the cell cycle is proposed that incorporates the known biochemical reactions involving both cyclin A and cyclin B, the interactions of these cyclins with cdc2 and cdk2, and the controlling effects of cdc25 and weel. The model also postulates the existence of an as yet unknown phosphatase involved in the formation of maturation promoting factor. The model produces solutions that agree qualitatively with a wide variety of experimentally observed cell‐cycle behavior. Conditions under which the model could explain the initial rapid divisions of embryonic cells and the transition to the slower somatic cell cycle are also discussed.