Open AccessIn vitro tumour cell growth inhibition: a comparative study between allosensitized cytotoxic T lymphocytes and lymphokine activated killer cells
Author(s) -
Fuggetta M. P.,
Alvino E.,
Pepponi R.,
De Filippi R.,
Marini S.,
Bonmassar E.
Publication year - 1993
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1993.tb00326.x
Subject(s) - lymphokine activated killer cell , cytotoxic t cell , lymphokine , ctl* , biology , natural killer t cell , major histocompatibility complex , immunology , interleukin 2 , interleukin 21 , in vitro , microbiology and biotechnology , immune system , biochemistry
There is general agreement that several distinct subpopulations of lymphocytes, including major histocompatibility complex (MHC)‐restricted T lymphocytes and non‐restricted natural killer, or lymphokine‐activated killer (LAK), cells are active in lysing neoplastic cells. In this study experiments were designed to compare the inhibitory effects of LAK cells and allosensitized cytotoxic T lymphocytes (CTL) on in vitro growth of an Epstein–Barr virus‐transformed B‐cell line (BSM) and of a HTLV‐I producer T‐cell line (MT‐2). It was found that allosensitized CTL are more efficient at inducing BSM, or MT‐2, cell growth inhibition than LAK cells. These results are consistent with the hypothesis that MHC‐restricted T effector cells could mediate higher tumour suppressive effects than non‐MHC restricted LAK cells.