Open AccessThe influence of cell co‐operation, nutrients and surface area on cell division
Author(s) -
Blomquist E.,
Brunk U.,
MacieiraCoelho A.
Publication year - 1993
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1993.tb00004.x
Subject(s) - cell division , division (mathematics) , cell , cycling , cell growth , life span , cell cycle , biology , microbiology and biotechnology , biological system , nutrient , biophysics , ecology , biochemistry , mathematics , evolutionary biology , history , arithmetic , archaeology
. Two opposite views have been proposed to explain the decline of the growth potential in cell populations with a limited life span: 1 variations in the probability of cycling and in cycling times or 2 a progressive increase in the nondividing cell fraction. Human brain‐derived cells were studied with respect to their proliferative potential under the influence of different growth conditions, using haptotactic palladium islands on agarose. The results emphasize the need for cell co‐operation, surface area and nutrients for cell division. These parameters also influence the final cell density. The results illustrate the multiple factors that can vary the probability of initiating the division cycle and stress the uncertainty of defining the irreversible non‐dividing state.