Open AccessProbability of self‐renewing divisions of spermatogonial stem cells in colonies, formed after fission neutron irradiation
Author(s) -
Beek M. E. A. B.,
Meistrich M. L.,
Rooij D. G.
Publication year - 1990
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1990.tb01105.x
Subject(s) - biology , fission , stem cell , irradiation , cell division , neutron irradiation , microbiology and biotechnology , neutron , genetics , cell , physics , nuclear physics
. Repopulating spermatogenic colonies, found in the seminiferous epithelium after irradiation with fast‐fission neutrons, were studied to determine the cha nce that a stem cellA single (A s spermatogonium would complete a self‐renewing division (P). Mathematical formulas originally derived for such studies in haemopoietic colonies were employed, and a method specifically aimed at spermatogenic colonies was developed. The results showed that during the first division after irradiation, P is close to 1 ‐0. P decreases in later generations, but remains 0‐7 or higher up to the 4th or 5th divisions. The mean value for P was over 0‐8, which is higher than the value of 0‐6‐0‐7 found for stem cells in haemopoietic colonies.