Open AccessPersistent Dose‐Dependent Increases In Cycling of Haemopoietic Precursor Cells After Irradiation
Author(s) -
Tejero C.,
Hendry J. H.,
Testa N. G.
Publication year - 1988
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1988.tb00858.x
Subject(s) - thymidine , irradiation , precursor cell , granulocyte , cycling , stem cell , andrology , rapid cycling , macrophage , chemistry , biology , immunology , microbiology and biotechnology , medicine , cell , endocrinology , biochemistry , in vitro , history , physics , archaeology , bipolar disorder , lithium (medication) , nuclear physics
Between 3 weeks and 36 months after irradiation of mice, there was a dose‐dependent increased level of cycling in haemopoietic stem cells (CFU‐S) and in granulocyte‐macrophage precursor cells (GM‐CFC). For CFU‐S the percentage kill measured using the thymidine suicide technique increased from about 10% in controls to a high and persistent average level of about 45% after 10 Gy γ‐rays, and for GM‐CFC the increase was from about 30% to about 50%.