Open AccessThe Cell Cycle Time In Intestinal Crypts By Simulation of Flm Experiments
Author(s) -
Meinzer H. P.,
Chen W.,
Sandblad B.,
Wright N.
Publication year - 1988
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1988.tb00803.x
Subject(s) - mitosis , dilution , phase (matter) , cell cycle , biology , biological system , microbiology and biotechnology , chemistry , cell , physics , thermodynamics , biochemistry , organic chemistry
. A computer program is developed that permits simulation of the dynamic behaviour of cells in intestinal crypts (Meinzer & Sandblad, 1985). Here we present the simulation of FLM data which is compared with the experimental findings of Al‐Dewachi et al. (1974). the phase durations and total cycle times of cells in the jejunal crypts of rats were calculated. Additionally, the influence of various control parameters on the simulation output is discussed, e.g. the standard errors of phase times and the grain dilution at mitosis.