Open AccessThe Growth and Life of A Monoclonal Crypt
Author(s) -
Chen W.,
Meinzer H. P.,
Sandblad B.
Publication year - 1988
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1988.tb00802.x
Subject(s) - crypt , mitotic index , analogy , biology , mitosis , mechanism (biology) , andrology , microbiology and biotechnology , endocrinology , physics , medicine , linguistics , philosophy , quantum mechanics
. A computer simulation of a highly dynamic model for the birth, growth and adult life of a monoclonal crypt in the intestine was developed starting with a single precursor stem cell. the intestinal epithelial system was studied and observed in analogy to ‘ in vivo ’ experiments. the model output, e.g. the geometric shape of a crypt, mitotic index, labelling index and the crypt length distribution in adult state, was compared with experimental data. There was evidence from the simulation that a certain steady state in the adult life could be reached regardless of some harmless influences in post‐natal life, e.g. the influence of being weaned or non‐weaned. the model is based on our hypothesis of the generation‐controlled proliferation mechanism and at the same time is a confirmation of it.