Open AccessMathematical Analysis of Haemopoietic Grafted Cell Renewal and Migration Through the Allogeneic Or Syngeneic Mouse Host
Author(s) -
Spach C.,
Motta R.
Publication year - 1988
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1988.tb00787.x
Subject(s) - biology , host (biology) , immunology , microbiology and biotechnology , transplantation , virology , genetics , medicine , surgery
. A mathematical analysis of results from kinetic studies of 125‐iododeoxyuri‐dine uptake and loss in almost all the lymphoid and non‐lymphoid organs of mice is described. Applied to data gathered from a graft‐ versus ‐host reaction experiment, this analysis affords quantitative precision on the differential effects of organ alloantigens on the proliferating grafted cells. It is shown that, depending on the organ and the post‐graft period, cell growth can be ascribed to alloantigen‐driven cell renewal or to alloantigen‐driven trapping or sequestration. Possible applications of the present approach in graft rejection monitoring are discussed.