Open AccessIn vitro effect of a glycopeptide acting in vivo on hepatocyte cell cycle
Author(s) -
Lombard M.N.,
Nadal C.,
Monnot M.J.
Publication year - 1987
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1987.tb01358.x
Subject(s) - in vivo , hepatocyte , in vitro , dna synthesis , microbiology and biotechnology , cell cycle , cell , cell culture , hepatocyte growth factor , chemistry , cell growth , glycopeptide , biology , biochemistry , receptor , genetics , antibiotics
A factor specifically inhibiting the hepatocyte cell cycle in vivo was found to block the G1‐S transition of liver cells in vitro . It proved to be non‐toxic in our culture conditions, as judged by the reversibility of the effect on cell proliferation. It was not active on DNA synthesis in fibroblastic cell lines (3T3).