Open AccessRegulation of recovery in the erythroid lineage: model studies
Author(s) -
Tyazhelova V. G.
Publication year - 1987
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1987.tb01328.x
Subject(s) - erythropoietin , progenitor cell , population , erythropoiesis , microbiology and biotechnology , biology , progenitor , immunology , function (biology) , haematopoiesis , regeneration (biology) , chemistry , endocrinology , stem cell , medicine , environmental health , anemia
Abstract. Based on data from the literature, the major regulatory features were established for the erythroid population regenerating after perturbation. A mathematical model is proposed which takes into account: (1) the increase in the proliferating CFU‐S due to depopulation of CFU‐S and BFU‐E/8 pools due to increased migration caused by erythropoietin; (2) regeneration of erythroid precursors due to short‐range factors and (3) gradual reduction in the short‐range effects and increase in the humoral influence on BFU‐E/8, BFU‐E/3 and CFU‐E together with short‐range suppression of progenitor differentiation and acceleration of maturation in all subpopulations due to humoral factors. The kinetics of subpopulations as a function of feedback and maturation rate are analysed. The dependence of erythrocyte production on erythrocyte depletion in the blood and on the feedback coefficient is defined.