Open AccessDetermination of proliferative parameters from growth curves
Author(s) -
Cowan R.,
Morris V. B.
Publication year - 1987
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1987.tb01094.x
Subject(s) - cell growth , cell division , biology , period (music) , cell , andrology , biological system , immunology , mathematics , microbiology and biotechnology , genetics , medicine , physics , acoustics
. Data on total cell numbers and proportions of non‐proliferative cells during the development of a tissue can be obtained by experiment. This paper shows, via a simple mathematical model, that data collected over a period of time determine the time profile of two proliferative parameters. These are the rate per proliferative cell per day at which cells divide and the average number of proliferative daughters which result from the division of a proliferative cell. One dataset alone does not provide sufficient information to determine either time profile. The findings are applicable where there is no significant cell death during the growth period. The mathematical model is fitted to data from chick neural retina.