Open AccessSome Long‐Term Cell Kinetic Effects of Ionizing Radiation On Mouse Bladder Urothelium
Author(s) -
Reitan J. B.
Publication year - 1986
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1986.tb00750.x
Subject(s) - urothelium , ionizing radiation , term (time) , radiobiology , biology , microbiology and biotechnology , irradiation , medicine , radiation therapy , anatomy , urinary system , physics , nuclear physics , quantum mechanics
. The cell kinetics of the mouse bladder urothelium were followed with tritiated thymidine pulse labelling and flow cytometry for one year after irradiation with electrons. No perturbations were registered after 10 Gy. Three to four weeks after 20 Gy an elevation of the labelling index with a subsequent return to normal was seen. Flow cytometry revealed some increase in the proportion of octaploid nuclei at the same time. From about six months after irradiation the normal polyploidization decreased. the urothelium turned into a mainly diploid cell population. the proportion of diploid S phase cells also increased. the data give some support to the model hypothesis of reactive proliferation in a ‘flexible’ tissue, according to Wheldon et al. (1982).